Oxidative Stress and Antioxidant Status in Acute and Chronic Myeloid Leukemia Patients

Rajeshwari, Ullagaddi and Shobha, Iyer and Raghunatha, Rao and Andallu, Bondada (2013) Oxidative Stress and Antioxidant Status in Acute and Chronic Myeloid Leukemia Patients. Open Journal of Blood Diseases, 03 (03). pp. 17-22. ISSN 2164-3180

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Abstract

Oxidative stress, a pervasive condition of increased number of reactive oxygen species, is now recognized to be prominent feature of various diseases and their progression. The relationship between antioxidants and levels of well-known markers of oxidative stress, measured as lipid peroxides and oxidized proteins reflect health indices. The aim of this study is to evaluate the extent of oxidative stress and antioxidant status in acute and chronic myeloid leukemia patients. The present study included 60 patients selected using standard questionnaire based on age, family history, Body Mass Index (BMI), dietary intake, with no other complications and 30 age and sex-matched healthy subjects. The median age of myeloid leukemia patients was 43 years and that of controls was 42 years. Out of 60 myeloid leukemia patients, 30 were in acute and 30 were in chronic state. Oxidative stress and antioxidant status were evaluated in the patients and in the controls by assessing standard oxidative stress markers viz. plasma and erythrocyte lipid peroxide levels in terms of malondialdehyde and oxidized proteins as protein carbonyls whereas antioxidant status was assessed in terms of serum non enzymatic antioxidant levels. There was a significant increase (p < 0.01) in plasma and erythrocyte lipid peroxidation and protein oxidation in acute and chronic myeloid leukemia patients as compared to healthy subjects. Antioxidant status as indicated by the levels of non-enzymatic antioxidants viz. erythrocyte reduced glutathione (GSH), serum β carotene, vitamin A & C and ceruloplasmin was found to be significantly decreased (p < 0.01) in both the leukemia patients as compared to healthy participants. However, chronic myeloid leukemia patients had significantly (p < 0.05) higher oxidative stress and lower antioxidant status as compared to acute myeloid leukemia patients.

Item Type: Article
Subjects: Afro Asian Library > Medical Science
Depositing User: Unnamed user with email support@afroasianlibrary.com
Date Deposited: 13 Apr 2023 07:22
Last Modified: 05 Jul 2024 07:17
URI: http://classical.academiceprints.com/id/eprint/478

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