Histopathological Changes on Testes, Liver, Kidney and Brain Tissues in Acute Boric Acid Administration

Introduction: In recent years as a result of the observation that the toxic effects of boron and its products have increased intensive studies have been initiated in our country and in the world regarding its effects, especially in the central nervous system, digestive system and reproductive system. The aim was to determine the histopathological changes caused by boric acid in rat testis, liver, kidney and brain tissues by light microscopy after oral administration of toxic dose of acute boric acid.

Material and Methods: In the study, 1000 mg/kg/day boric acid was given orally for 7 days to 12-week-old 30 male albino SpragueDawley rats in total with an average weight of 285 g. Twelve male albino Sprague-Dawley rats of approximately the same weight and age were used as controls. At the end of the seventh day testes, liver, kidney and brain tissues were isolated from the animals.

Results: At the end of the experiment, it was determined that the experimental group had significant body weight loss compared to the control group. Likewise, testicular, liver and kidney weights of the experimental group were decreased compared to the controls. In the histopathological examination performed with light microscopy in the testis, liver, kidney and brain tissues taken, congestion in the vascular bed of the testicular tissue and cellular degeneration at different rates were observed in paraffin sections and semi-thin sections.

Conclusion: It was observed that acute boric acid administration, together with its widespread toxic effect, caused histopathological changes by inhibiting spermatogenesis, especially in testicular tissue.