The Effect of Curcumin on the Invasion and Migration of Glioma Cells

Zraikat, Manar and Gharaibeh, Munir and Alshelleh, Tasneem (2020) The Effect of Curcumin on the Invasion and Migration of Glioma Cells. European Journal of Medicinal Plants, 31 (7). pp. 11-16. ISSN 2231-0894

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Official URL: https://doi.org/10.9734/ejmp/2020/v31i730249

Abstract

Aim: This study investigated the effect of curcumin, from Curcuma longa, on the invasion of U87 glioma cell line spheres in 3D collagen model. Furthermore, this study investigated the anti-migration effects of curcumin on the migration of the same cell line in scratch assay.

Place and Duration of Study: Department of Pharmacology, School of Medicine, The University of Jordan, Amman, Jordan, between March 2019 and May 2019.

Methods: 3D invasion assay and 2D migration assays were used to fulfill these aims in addition to the Image J program that was used to analyze the area of invasion and the area of migration over the days of applying the assays.

Results: The results showed an inhibitory effect of curcumin in all samples tested on both the invasion and migration of U87 cell line.

Conclusion: This work adds more proofs on the importance of curcumin as anti-invasive and anti-migration agent and opens the door for more investigative studies.

Item Type:	Article
Subjects:	Afro Asian Library > Medical Science
Depositing User:	Unnamed user with email support@afroasianlibrary.com
Date Deposited:	03 Apr 2023 08:07
Last Modified:	01 Jul 2024 13:25
URI:	http://classical.academiceprints.com/id/eprint/226

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