Goserelin acetate before transurethral resection of moderately enlarged benign prostatic hyperplasia: Prospective randomised-controlled clinical trial

Abo El-Enen, Mohamed and Tawfik, Ahmed and El-Abd, Ahmed S. and Ragab, Maged and El-Abd, Sherin and Elrashidy, Mohamed and Elmashad, Nehal and Rasheed, Mohamed and El-Abd, Shawky (2016) Goserelin acetate before transurethral resection of moderately enlarged benign prostatic hyperplasia: Prospective randomised-controlled clinical trial. Arab Journal of Urology, 14 (1). pp. 59-65. ISSN 2090-598X

[thumbnail of Goserelin acetate before transurethral resection of moderately enlarged benign prostatic hyperplasia Prospective randomised controlled clinical trial.pdf] Text
Goserelin acetate before transurethral resection of moderately enlarged benign prostatic hyperplasia Prospective randomised controlled clinical trial.pdf - Published Version

Download (2MB)

Abstract

Objective: To evaluate the impact of a luteinising hormone-releasing hormone (LHRH) agonist, goserelin acetate (GA), on surgical blood loss during transurethral resection of the prostate (TURP), as well as its histopathological effect on prostatic microvessel density (MVD).

Patients and methods: Patients who underwent TURP due to benign prostatic enlargement (60–100 mL) were randomly subdivided into two equal groups according to whether they received preoperative GA administration (3.6 mg; group A) or not (group B). Evaluation parameters were operative time, weight of resected prostatic tissue, perioperative haematocrit (HCT) changes, estimation of intraoperative blood loss, and suburethral and stromal prostatic MVD. Effects of GA on prostate weight and any possible side-effects were also monitored.

Results: In all, 35 and 33 patients were included in groups A and B, respectively. Operative time and HCT values’ changes were significantly less in group A (P < 0.05). Also, operative blood loss (both total and adjusted per weight of resected tissue) was lower in group A, at a mean (SD) of 178.13 (77.71) mL and 3.74 (1.52) mL/g vs 371.75 (91.09) mL and 8.59 (2.42) mL/g (P < 0.001). The median MVD in both suburethral [8 vs 11 vessels/high-power field (HPF)] and stromal tissues (9 vs 17 vessels/HPF) were significantly lower in group A (P < 0.001). Side-effects were minimal.

Conclusion: A single dose of GA, a LHRH agonist, before TURP is safe and effective in reducing surgical blood loss. It significantly reduced MVD in both suburethral and stromal nodular prostatic tissues without regional discrepancy.

Item Type: Article
Subjects: Afro Asian Library > Medical Science
Depositing User: Unnamed user with email support@afroasianlibrary.com
Date Deposited: 15 Jul 2023 12:10
Last Modified: 28 May 2024 05:49
URI: http://classical.academiceprints.com/id/eprint/1286

Actions (login required)

View Item
View Item