Anti-oxidant and Anti-inflammatory Activity of Cassia auriculata (Flowers)

Aim: To analyze the antioxidants and anti-inflammatory potential of ethanolic crude extract of Cassia auriculata flowers.

Study Design: 2 kg of fresh flowers were soaked with 90% ethanol at room temperature (25ºC-30ºC). After 72 hrs the ethanolic extract was filtered. This extract was distilled and finally the crude was obtained. This ethanolic crude to get required concentrations and were used for screening antioxidants and anti-inflammatory activities.

Place and Duration of Study: PG & Research Department of Chemistry, Periyar E.V.R. College (Autonomous), Trichy, Tamilnadu, India. During the month of August and September 2014.

Methodology: Fresh flowers of Cassia auriculata were extracted with ethanol and evaluated for antioxidant activities by 2,2-Diphenyl 1-picryl hydrazyl solution (DPPH), 2,2'-azino-bis(3-ethylbenzthiazoline-6-sul- phonic acid (ABTS) assay and anti inflammatory activites by humen blood cell (HRBC) membrane stabilization method and Inhibition of albumin denaturation method.

Results: The results obtained showed that the ethanolic crude extract of Cassia auriculata flowers can be considered as good sources of anti-oxidants, anti-inflammatory and can be incorporated into the drug formulations.

Conclusion: This study justifies the anti-oxidants, anti-inflammatory activity of ethanolic crude extract of Cassia auriculata Flowers. Further detailed analysis of this sample is required to identify the presence of bioactive compounds responsible for anti-oxidants, anti-inflammatory activities. Studies are highly needed for future drug development.